January 2016-1: Publication in Angewandte Chemie Int. Ed.
The implementation of a one-pot multi-enzyme cascade in a single bacterial whole cell system has been recently published in Angewandte Chemie Int. Ed. (DOI: 10.1002/anie.201510028). In this research, a P450 monooxygenase, an alcohol dehydrogense and an omega-transaminase have been cloned in the same host organism to carry out the formal regio- and stereoselective amination of benzylic C-H bonds. This research was performed in collaboration with the University of Manchester (Prof. S. L. Flitsch)